abstract：:Entamoeba histolytica is a protozoan parasite and a major cause of dysentery and diarrheal disease in developing countries. Disease transmission from one host to another occurs via cysts which can survive in environmental extremes and are transmitted through contaminated food and water. Recent studies in our lab ident...

journal_title：Frontiers in cellular and infection microbiology

authors： Manna D,Lozano-Amado D,Ehrenkaufer G,Singh U

更新日期：2020-07-17 00:00:00

abstract：:The Mycobacterium fortuitum complex comprises several closely related species, causing pulmonary and extra-pulmonary infections. However, there is very limited knowledge about the disease pathogenesis involved in M. fortuitum infections, particularly due to the lack of suitable animal models. Using the zebrafish model...

journal_title：Frontiers in cellular and infection microbiology

authors： Johansen MD,Kremer L

更新日期：2020-07-17 00:00:00

abstract：:Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical research fields. Many studies have reported the existence of EVs in all types of living cells, including in fifteen different fungal genera. EVs play diverse biological roles, from the regulation of physiological events and res...

journal_title：Frontiers in cellular and infection microbiology

authors： Rizzo J,Rodrigues ML,Janbon G

更新日期：2020-07-15 00:00:00

abstract：:Influenza is a major public health problem that causes acute respiratory infection in humans. Identification of host factors influencing in disease outcome is critical for recognition of individuals with increased risk. Investigations on the role of rs34481144A and rs12252C IFITM3 polymorphisms in influenza A(H1N1)pdm...

journal_title：Frontiers in cellular and infection microbiology

authors： Martins JSC,Oliveira MLA,Garcia CC,Siqueira MM,Matos AR

更新日期：2020-07-10 00:00:00

abstract：:Streptococcus mutans is an oral species closely associated with dental caries. As an early oral colonizer, S. mutans utilizes interspecies coaggregation to promote the colonization of subsequent species and affect polymicrobial pathogenesis. Previous studies have confirmed several adhering partner species of S. mutans...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu T,Liu J,Liu J,Yang R,Lu X,He X,Shi W,Guo L

更新日期：2020-07-07 00:00:00

abstract：:Gut microbiota serves as a critical indicator for gut health during treatment of pathogenic bacterial infection. Both Pulsatilla Decoction (abbreviated to PD, a traditional Chinese medicine compound) and Levofloxacin Hydrochloride (LVX) were known to have therapeutic effects to intestinal infectious disease. However, ...

journal_title：Frontiers in cellular and infection microbiology

authors： Liu X,He S,Li Q,Mu X,Hu G,Dong H

更新日期：2020-06-30 00:00:00

abstract：:Esophageal microbiota plays important roles in esophageal cancer. Esophagectomy, as the most important therapeutic way, contributes to changes of esophageal microbiome. However, there are few studies examining the esophageal microbiome and the metabolic changes before and after esophagectomy. The present study charact...

journal_title：Frontiers in cellular and infection microbiology

authors： Li D,He R,Hou G,Ming W,Fan T,Chen L,Zhang L,Jiang W,Wang W,Lu Z,Feng H,Geng Q

更新日期：2020-06-26 00:00:00

abstract：:Herpes simplex virus-1 (HSV-1) is a significant human pathogen. Upon infection, HSV-1 expresses its immediate early (IE) genes, and the IE transcription factor ICP4 (infectious cell protein-4) plays a pivotal role in initiating the downstream gene-expression cascade. Using live-cell time-lapse fluorescence microscopy,...

journal_title：Frontiers in cellular and infection microbiology

authors： Chaturvedi S,Engel R,Weinberger L

更新日期：2020-06-24 00:00:00

abstract：:Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated. Gaining proper insight into host-pathogen interactions and identifying chief ...

journal_title：Frontiers in cellular and infection microbiology

authors： Younes S,Al-Sulaiti A,Nasser EAA,Najjar H,Kamareddine L

更新日期：2020-06-23 00:00:00

abstract：:Toxoplasma gondii has been found to infect almost all warm-blooded animals, including humans. In this study, a total of 3,275 human serum samples were collected from hospitals in five provinces of China. About 5.13% (168/3,275) (95% CI, 4.42-5.94) of the serum samples tested positive for T. gondii IgG antibody by a mo...

journal_title：Frontiers in cellular and infection microbiology

authors： Xin S,Su R,Jiang N,Zhang L,Yang Y

更新日期：2020-06-23 00:00:00

abstract：:Preterm infants are exposed to major perinatal, post-natal, and early infancy events that could impact on the gut microbiome. These events include infection, steroid and antibiotic exposure, parenteral nutrition, necrotizing enterocolitis, and stress. Studies have shown that there are differences in the gut microbiome...

journal_title：Frontiers in cellular and infection microbiology

authors： Jayasinghe TN,Vatanen T,Chiavaroli V,Jayan S,McKenzie EJ,Adriaenssens E,Derraik JGB,Ekblad C,Schierding W,Battin MR,Thorstensen EB,Cameron-Smith D,Forbes-Blom E,Hofman PL,Roy NC,Tannock GW,Vickers MH,Cutfield WS,O'Sul

更新日期：2020-06-16 00:00:00

abstract：:Shiga toxin (Stx)-producing Escherichia coli (STEC) O157:H7 is an enteric pathogen that causes life-threatening disease in humans, with cattle being major natural reservoirs. A group of STEC O157:H7 with a dramatic combination of high virulence potentials and super-shedder bovine origin have been isolated. Here, an ST...

journal_title：Frontiers in cellular and infection microbiology

authors： Teng L,Lee S,Park D,Jeong KC

更新日期：2020-06-05 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fcimb.2017.00464.]. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Meuskens I,Michalik M,Chauhan N,Linke D,Leo JC

更新日期：2020-06-03 00:00:00

abstract：:Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive, multifaceted crosstalk between pyroptosis, apoptosis, and necroptosis, three programmed cell death pathways traditionally considered autonomous. The growing body of ...

journal_title：Frontiers in cellular and infection microbiology

authors： Christgen S,Zheng M,Kesavardhana S,Karki R,Malireddi RKS,Banoth B,Place DE,Briard B,Sharma BR,Tuladhar S,Samir P,Burton A,Kanneganti TD

更新日期：2020-05-29 00:00:00

abstract：:To discern if there was a particular genotype associated with clinical enteroaggregative Escherichia coli (EAEC) strains isolated from deployed military personnel (DMP) with travelers' diarrhea (TD), we characterized a collection of EAEC from DMP deployed to Afghanistan, Djibouti, Kenya, or Honduras. Although we did n...

journal_title：Frontiers in cellular and infection microbiology

authors： Petro CD,Duncan JK,Seldina YI,Allué-Guardia A,Eppinger M,Riddle MS,Tribble DR,Johnson RC,Dalgard CL,Sukumar G,Connor P,Boisen N,Melton-Celsa AR

更新日期：2020-05-20 00:00:00

abstract：:Natural killer (NK) cells are critical for targeting and killing tumor, virus-infected and stressed cells as a member of the innate immune system. Recently, NK cells have also emerged as key regulators of adaptive immunity and have become a prominent therapeutic target for cancer immunotherapy and infection control. N...

journal_title：Frontiers in cellular and infection microbiology

authors： Pierce S,Geanes ES,Bradley T

更新日期：2020-05-19 00:00:00

abstract：:Objectives:Pneumocystis jirovecii pneumonia (PCP) is an AIDS-defining illness. In patients with HIV, the benefit of PCP prophylaxis is well-defined when the CD4 T-cell count decreases below 200 cells/μL. In other immunocompromised patients, the value of PCP prophylaxis is not always as well-established. This study aim...

journal_title：Frontiers in cellular and infection microbiology

authors： Dunbar A,Schauwvlieghe A,Algoe S,van Hellemond JJ,Reynders M,Vandecasteele S,Boelens J,Depuydt P,Rijnders B

更新日期：2020-05-15 00:00:00

abstract：:Candida species are known to differ in their ability to cause infection and have been shown to display varied susceptibilities to antifungal drugs. Treatment with the echinocandin, caspofungin, leads to compensatory alterations in the fungal cell wall. This study was performed to compare the structure and composition ...

journal_title：Frontiers in cellular and infection microbiology

authors： Walker LA,Munro CA

更新日期：2020-05-12 00:00:00

abstract：:Culture-independent metagenomic methodologies have enabled detection and identification of microorganisms in various biological systems and often revealed complex and unknown microbiomes. In many organisms, the microbiome outnumbers the host cells and greatly affects the host biology and fitness. Ticks are hematophago...

journal_title：Frontiers in cellular and infection microbiology

authors： Guizzo MG,Neupane S,Kucera M,Perner J,Frantová H,da Silva Vaz I,de Oliveira PL,Kopacek P,Zurek L

更新日期：2020-05-08 00:00:00

abstract：:Additional research on soft ticks in the family Argasidae is needed to bridge the knowledge gap relative to hard ticks of the family Ixodidae; especially, the molecular mechanisms of Ornithodoros biology. Ornithodoros species are vectors of human and animal pathogens that include tick-borne relapsing fever spirochetes...

journal_title：Frontiers in cellular and infection microbiology

authors： Armstrong BA,Kneubehl AR,Mitchell RD 3rd,Krishnavajhala A,Teel PD,Pérez de León AA,Lopez JE

更新日期：2020-05-05 00:00:00

abstract：:During chronic human immunodeficiency virus type 1 (HIV-1) infection, upregulation of inhibitory molecules contributes to effector cell dysfunction and exhaustion. This, in combination with the ability of HIV-1 to reside dormant in cellular reservoirs and escape immune recognition, makes the pathway to HIV-1 cure part...

journal_title：Frontiers in cellular and infection microbiology

authors： Holder KA,Grant MD

更新日期：2020-05-05 00:00:00

abstract：:Vibrio alginolyticus is a major cause of Vibriosis in farmed marine aquatic animals and has caused large economic losses to the Asian aquaculture industry in recent years. Therefore, it is necessary to control V. alginolyticus effectively. The virulence mechanism of V. alginolyticus, the Type III secretion system (T3S...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhou S,Tu X,Pang H,Hoare R,Monaghan SJ,Luo J,Jian J

更新日期：2020-04-28 00:00:00

abstract：:Mycoplasma hyopneumoniae (M. hyopneumoniae) is the causative agent of pandemic pneumonia among pigs, namely, swine enzootic pneumonia. Although M. hyopneumoniae was first identified in 1965, little is known regarding its metabolic pathways, which might play a pivotal role during disease pathogenesis. Lipoate is an ess...

journal_title：Frontiers in cellular and infection microbiology

authors： Zhu K,Chen H,Jin J,Wang N,Ma G,Huang J,Feng Y,Xin J,Zhang H,Liu H

更新日期：2020-04-21 00:00:00

abstract：:Acute pancreatitis (AP) is considered a cascade of immune responses triggered by acinar cell necrosis. AP involves two main processes of systemic inflammatory response syndrome and subsequent compensatory anti-inflammatory response syndrome. Although great efforts have been made regarding AP therapy, the mortality rat...

journal_title：Frontiers in cellular and infection microbiology

authors： Ding L,Yang Y,Li H,Wang H,Gao P

更新日期：2020-03-31 00:00:00

abstract：:Background: Several studies suggested an important role of the gut microbiota in the pathophysiology of neurological disorders, implying that alteration of the gut microbiota might serve as a treatment strategy. Fecal microbiota transplantation (FMT) is currently the most effective gut microbiota intervention and an a...

journal_title：Frontiers in cellular and infection microbiology

authors： Vendrik KEW,Ooijevaar RE,de Jong PRC,Laman JD,van Oosten BW,van Hilten JJ,Ducarmon QR,Keller JJ,Kuijper EJ,Contarino MF

更新日期：2020-03-24 00:00:00

abstract：:Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), which leads to an estimated 1. 5 million deaths worldwide each year. Although the immune correlates of protection against Mtb infection and TB disease have not been well-defined, natural killer (NK) cells are increasingly recognized as a key...

journal_title：Frontiers in cellular and infection microbiology

authors： Harris LD,Khayumbi J,Ongalo J,Sasser LE,Tonui J,Campbell A,Odhiambo FH,Ouma SG,Alter G,Gandhi NR,Day CL

更新日期：2020-03-24 00:00:00

abstract：:Response regulators are a critical part of the two-component system of gene expression regulation in bacteria, transferring a signal from a sensor kinase into DNA binding activity resulting in alteration of gene expression. In this study, we investigated a previously uncharacterized response regulator in Francisella n...

journal_title：Frontiers in cellular and infection microbiology

authors： Dean SN,Milton ME,Cavanagh J,van Hoek ML

更新日期：2020-03-13 00:00:00

abstract：:Lipids are essential players in parasites pathogenesis. In particular, the highly phagocytic trophozoites of Entamoeba histolytica, the causative agent of amoebiasis, exhibit a dynamic membrane fusion and fission, in which lipids strongly participate; particularly during the overstated motility of the parasite to reac...

journal_title：Frontiers in cellular and infection microbiology

authors： Castellanos-Castro S,Bolaños J,Orozco E

更新日期：2020-03-10 00:00:00

abstract：:Lipophilic yeasts of the genus Malassezia are important skin commensals and opportunistic skin pathogens in a variety of animals. The species M. pachydermatis was first isolated from the skin of a captive Indian rhinoceros with an exfoliative dermatitis in 1925, recognized as an important otic pathogen of dogs in the ...

journal_title：Frontiers in cellular and infection microbiology

authors： Guillot J,Bond R

更新日期：2020-02-28 00:00:00

abstract：:Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA gene, was identified as a de...

journal_title：Frontiers in cellular and infection microbiology

authors： Yu W,Li D,Li H,Tang Y,Tang H,Ma X,Liu Z

更新日期：2020-02-28 00:00:00

abstract：:Background and Purpose: Early life microbiota plays a crucial role in human health by acting as a barrier from pathogens' invasion and maintaining the intestinal immune homoeostasis. Altered fecal microbiota (FM) ecology was reported in newborns affected by intestinal ischemia. Our purpose was to describe, in these pa...

journal_title：Frontiers in cellular and infection microbiology

authors： Romani L,Del Chierico F,Chiriaco M,Foligno S,Reddel S,Salvatori G,Cifaldi C,Faraci S,Finocchi A,Rossi P,Bagolan P,D'Argenio P,Putignani L,Fusaro F

更新日期：2020-02-25 00:00:00

abstract：:For decades, mass drug treatment with praziquantel (PZQ) has been utilized to treat schistosomiasis, yet reinfection and the risk of drug resistance are among the various factors precluding successful elimination of schistosomiasis. Tractable models that replicate "real world" field conditions are crucial to effective...

journal_title：Frontiers in cellular and infection microbiology

authors： Melkus MW,Le L,Siddiqui AJ,Molehin AJ,Zhang W,Lazarus S,Siddiqui AA

更新日期：2020-02-24 00:00:00

abstract：:In this original study, we retrospectively reviewed the cases of nocardiosis diagnosed through culture and next-generation sequencing (NGS) methods between 2014 and 2018 in Huashan Hospital and found out that the latter way can not only improve the detection rate of Nocardia spp. but also greatly reduce the turnaround...

journal_title：Frontiers in cellular and infection microbiology

authors： Weng SS,Zhang HY,Ai JW,Gao Y,Liu YY,Xu B,Zhang WH

更新日期：2020-02-18 00:00:00

abstract：:Despite ongoing efforts, sub-Saharan Africa faces a higher cervical cancer burden than anywhere else in the world. Besides HPV infection, definitive factors of cervical cancer are still unclear. Particular states of the cervicovaginal microbiota and viral infections are associated with increased cervical cancer risk. ...

journal_title：Frontiers in cellular and infection microbiology

authors： Klein C,Kahesa C,Mwaiselage J,West JT,Wood C,Angeletti PC

更新日期：2020-02-12 00:00:00

abstract：:The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in immune compromised individuals. This pathogen is typically acquired via inhalation, and enters the respiratory tract. Innate immune cells such as macrophages and dendritic cells (DCs) are the first host cells that encounter C. neoform...

journal_title：Frontiers in cellular and infection microbiology

authors： Nelson BN,Hawkins AN,Wozniak KL

更新日期：2020-02-11 00:00:00

abstract：:Ocular toxoplasmosis is one of the most common complications caused by the infection with the parasite Toxoplasma gondii. The risk of developing eye lesions and impaired vision is considered higher in Brazil than other countries. The clinical diagnosis is difficult and the use of sensitive and specific laboratorial me...

journal_title：Frontiers in cellular and infection microbiology

authors： Murata FHA,Previato M,Frederico FB,Barbosa AP,Nakashima F,de Faria GM Jr,Silveira Carvalho AP,Meira Strejevitch CDS,Pereira-Chioccola VL,Castiglioni L,de Mattos LC,Siqueira RC,Brandão de Mattos CC

更新日期：2020-02-07 00:00:00

abstract：:Differentiation between mitis group streptococci (MGS) bacteria in routine laboratory tests has become important for obtaining accurate epidemiological information on the characteristics of MGS and understanding their clinical significance. The most reliable method of MGS species identification is multilocus sequence ...

journal_title：Frontiers in cellular and infection microbiology

authors： Imai K,Nemoto R,Kodana M,Tarumoto N,Sakai J,Kawamura T,Ikebuchi K,Mitsutake K,Murakami T,Maesaki S,Fujiwara T,Hayakawa S,Hoshino T,Seki M,Maeda T

更新日期：2020-01-30 00:00:00

abstract：:Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial communities that inhabit the gut and oral cavity. Mounting evidence su...

journal_title：Frontiers in cellular and infection microbiology

authors： Hammad DBM,Hider SL,Liyanapathirana VC,Tonge DP

更新日期：2020-01-22 00:00:00

abstract：:Pediculus humanus is an obligate bloodsucking ectoparasite of human that includes two ecotypes, head louse and body louse, which differ slightly in morphology and biology, but have distinct ecologies. Phylogenetically, they are classified on six mitochondrial clades (A, B, C, D, E, and F), head louse encompasses the f...

journal_title：Frontiers in cellular and infection microbiology

authors： Amanzougaghene N,Fenollar F,Raoult D,Mediannikov O

更新日期：2020-01-21 00:00:00

abstract：:Probiotics have been used to treat a variety of diseases for decades; however, what is the rationale for their application? Such a treatment was first proposed in the early nineteenth century based on observations of decreased bifidobacterial populations in children suffering from diarrhea, suggesting that oral intake...

journal_title：Frontiers in cellular and infection microbiology

authors： Wieërs G,Belkhir L,Enaud R,Leclercq S,Philippart de Foy JM,Dequenne I,de Timary P,Cani PD

更新日期：2020-01-15 00:00:00